Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase. Zhang J, Malik A, Choi HB, Ko RWY, Dissing- Olesen L, MacVicar BA. (2014) Neuron [Epub ahead of print]


Regenerative glutamate release by presynaptic NMDA receptors contributes to spreading depression. Zhou N , Rungta RL , Malik A , Han H , Wu DC , Macvicar BA, (2013). Journal of Cerebral Blood Flow and Metabolism. 33(10):1582-1594. doi:10.1038 PubMed ID 23820646

Increased 20-HETE Synthesis Explains Reduced Cerebral Blood Flow But Not Impaired   Neurovascular Coupling after Cortical Spreading Depression in Rat Cerebral Cortex.  Fordsmann JC , Ko RW , Choi HB , Thomsen K , Witgen BM , Mathiesen C , Lønstrup M , Piilgaard H , Macvicar BA , Lauritzen M, (2013) The Journal of Neuroscience : 33(6):2562-70. doi: 10.1523

Prevention of LPS induced microglia activation, cytokine production and sickness behavior with  TLR4 receptor interfering peptides.  DJ , Choi HB , Hines RM , Phillips AG , MacVicar BA (2013)PLoS One. 8(3):e60388. doi: 10.1371

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus. Zhu S, Tai C, Petkau TL, Zhang S, Liao C, Dong Z, Wen W, Chang Q, Tian Wang Y, Macvicar BA, Leavitt BR, Jia W, Cynader MS. Brain Res. 2013 Sep 12;1530:54-65. Epub 2013 Jul 22.

Prevention of LPS-induced microglia activation, cytokine production and sickness behavior with TLR4 receptor interfering peptides. Hines DJ, Choi HB, Hines RM, Phillips AG, MacVicar BA. PLoS One. 2013;8(3):e60388. Epub 2013 Mar 28.

Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex. Fordsmann JC, Ko RW, Choi HB, Thomsen K, Witgen BM, Mathiesen C, Lønstrup M, Piilgaard H, MacVicar BA, Lauritzen M. J Neurosci. 2013 Feb 6;33(6):2562-70.


Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA. Neuron. 2012 Sep 20;75(6):1094-104.


Glutathione restores the mechanism of synaptic plasticity in aged mice to that of the adult. Robillard JM, Gordon GR, Choi HB, Christie BR, MacVicar BA. PLoS One. 2011;6(5):e20676. Epub 2011 May 31.

A practical guide to the synthesis and use of membrane-permeant acetoxymethyl esters of caged inositol polyphosphates. Kantevari S, Gordon GR, MacVicar BA, Ellis-Davies GC. Nat Protoc. 2011 Mar;6(3):327-37. Epub 2011 Feb 17.

Bidirectional control of arteriole diameter by astrocytes. Gordon GR, Howarth C, MacVicar BA. Exp Physiol. 2011 Apr;96(4):393-9. Epub 2011 Jan 21.

Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons. Tai C, Hines DJ, Choi HB, MacVicar BA. Hippocampus. 2011 Sep;21(9):958-67. Epub 2010 Jun 1.


Glial and neuronal control of brain blood flow. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, Newman EA. Nature. 2010 Nov 11;468(7321):232-43. Review.

Contribution of calcium-dependent facilitation to synaptic plasticity revealed by migraine mutations in the P/Q-type calcium channel. Adams PJ, Rungta RL, Garcia E, van den Maagdenberg AM, MacVicar BA, Snutch TP. Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18694-9. Epub 2010 Oct 11.

Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression. Zhou N, Gordon GR, Feighan D, MacVicar BA. Cereb Cortex. 2010 Nov;20(11):2614-24. Epub 2010 Feb 22.

Non-junction functions of pannexin-1 channels. MacVicar BA, Thompson RJ. Trends Neurosci. 2010 Feb;33(2):93-102. Epub 2009 Dec 18. Review.


Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses. Gordon GR, Iremonger KJ, Kantevari S, Ellis-Davies GC, MacVicar BA, Bains JS. Neuron. 2009 Nov 12;64(3):391-403.

Microglia processes block the spread of damage in the brain and require functional chloride channels. Hines DJ, Hines RM, Mulligan SJ, Macvicar BA. Glia. 2009 Nov 15;57(15):1610-8.

Glutamatergic stimulation triggers rapid Krüpple-like factor 4 expression in neurons and the overexpression of KLF4 sensitizes neurons to NMDA-induced caspase-3 activity. Zhu S, Tai C, MacVicar BA, Jia W, Cynader MS. Brain Res. 2009 Jan 23;1250:49-62. Epub 2008 Nov 14.


Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus. Thompson RJ, Jackson MF, Olah ME, Rungta RL, Hines DJ, Beazely MA, MacDonald JF, MacVicar BA. Science. 2008 Dec 5;322(5907):1555-9.

Brain metabolism dictates the polarity of astrocyte control over arterioles. Gordon GR, Choi HB, Rungta RL, Ellis-Davies GC, MacVicar BA. Nature. 2008 Dec 11;456(7223):745-9. Epub 2008 Oct 29.

Connexin and pannexin hemichannels of neurons and astrocytes. Thompson RJ, Macvicar BA. Channels (Austin). 2008 Mar-Apr;2(2):81-6. Epub 2008 Mar 29. Review.

D1 receptors physically interact with N-type calcium channels to regulate channel distribution and dendritic calcium entry. Kisilevsky AE, Mulligan SJ, Altier C, Iftinca MC, Varela D, Tai C, Chen L, Hameed S, Hamid J, Macvicar BA, Zamponi GW. Neuron. 2008 May 22;58(4):557-70.

Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia. Iyirhiaro GO, Brust TB, Rashidian J, Galehdar Z, Osman A, Phillips M, Slack RS, Macvicar BA, Park DS. J Neurochem. 2008 May;105(3):703-13. Epub 2008 Jan 17.


C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. Brust TB, Cayabyab FS, MacVicar BA. Neuropharmacology. 2007 Dec;53(8):906-17. Epub 2007 Sep 20.

Astrocyte control of the cerebrovasculature. Gordon GR, Mulligan SJ, MacVicar BA. Glia. 2007 Sep;55(12):1214-21. Review.

Tumor-suppressive effects of pannexin 1 in C6 glioma cells. Lai CP, Bechberger JF, Thompson RJ, MacVicar BA, Bruzzone R, Naus CC. Cancer Res. 2007 Feb 15;67(4):1545-54.


p38 mitogen-activated protein kinase contributes to adenosine A1 receptor-mediated synaptic depression in area CA1 of the rat hippocampus. Brust TB, Cayabyab FS, Zhou N, MacVicar BA. J Neurosci. 2006 Nov 29;26(48):12427-38.

VRACs CARVe a path for novel mechanisms of communication in the CNS. Mulligan SJ, MacVicar BA. Sci STKE. 2006 Oct 17;2006(357):pe42. Review.

Neuroscience: controlled capillaries. MacVicar BA, Salter MW. Nature. 2006 Oct 12;443(7112):642-3.

Anion channels in astrocytes: biophysics, pharmacology, and function. Kimelberg HK, Macvicar BA, Sontheimer H. Glia. 2006 Nov 15;54(7):747-57. Review.

Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal neurons. Tai C, Kuzmiski JB, MacVicar BA. J Neurosci. 2006 Jun 7;26(23):6249-58.

Ischemia opens neuronal gap junction hemichannels. Thompson RJ, Zhou N, MacVicar BA. Science. 2006 May 12;312(5775):924-7.


Topiramate inhibits the initiation of plateau potentials in CA1 neurons by depressing R-type calcium channels. Kuzmiski JB, Barr W, Zamponi GW, MacVicar BA. Epilepsia. 2005 Apr;46(4):481-9.


Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Mulligan SJ, MacVicar BA. Nature. 2004 Sep 9;431(7005):195-9.


ATP released from astrocytes during swelling activates chloride channels. Darby M, Kuzmiski JB, Panenka W, Feighan D, MacVicar BA. J Neurophysiol. 2003 Apr;89(4):1870-7.

Expression of voltage-gated Ca2+ channel subtypes in cultured astrocytes. Latour I, Hamid J, Beedle AM, Zamponi GW, Macvicar BA. Glia. 2003 Mar;41(4):347-53.


Nitric oxide promotes intracellular calcium release from mitochondria in striatal neurons. Horn TF, Wolf G, Duffy S, Weiss S, Keilhoff G, MacVicar BA. FASEB J. 2002 Oct;16(12):1611-22.

Activation of presynaptic P2X7-like receptors depresses mossy fiber-CA3 synaptic transmission through p38 mitogen-activated protein kinase. Armstrong JN, Brust TB, Lewis RG, MacVicar BA. J Neurosci. 2002 Jul 15;22(14):5938-45.

Development of Ca2+ hotspots between Lymnaea neurons during synaptogenesis. Feng ZP, Grigoriev N, Munno D, Lukowiak K, MacVicar BA, Goldberg JI, Syed NI. J Physiol. 2002 Feb 15;539(Pt 1):53-65.

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. Panenka W, Jijon H, Herx LM, Armstrong JN, Feighan D, Wei T, Yong VW, Ransohoff RM, MacVicar BA. J Neurosci. 2001 Sep 15;21(18):7135-42.

Theta-frequency facilitation of AMPA receptor-mediated synaptic currents in the principal cells of the medial septum. Armstrong JN, MacVicar BA. J Neurophysiol. 2001 Apr;85(4):1709-18.

Serine/threonine protein phosphatases and synaptic inhibition regulate the expression of cholinergic-dependent plateau potentials. Fraser DD, Doll D, MacVicar BA. J Neurophysiol. 2001 Mar;85(3):1197-205.


Modulation of neuronal excitability by astrocytes. Duffy S, MacVicar BA. Adv Neurol. 1999;79:573-81. Review.

Glutamate release through volume-activated channels during spreading depression. Basarsky TA, Feighan D, MacVicar BA. J Neurosci. 1999 Aug 1;19(15):6439-45.

Imaging spreading depression and associated intracellular calcium waves in brain slices. Basarsky TA, Duffy SN, Andrew RD, MacVicar BA. J Neurosci. 1998 Sep 15;18(18):7189-99.

Biophysical and pharmacological characterization of voltage-dependent Ca2+ channels in neurons isolated from rat nucleus accumbens. Churchill D, Macvicar BA. J Neurophysiol. 1998 Feb;79(2):635-47.

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current. Crépel V, Panenka W, Kelly ME, MacVicar BA. J Neurosci. 1998 Feb 15;18(4):1196-206.

Neurotrophin modulation of NMDA receptors in cultured murine and isolated rat neurons. Jarvis CR, Xiong ZG, Plant JR, Churchill D, Lu WY, MacVicar BA, MacDonald JF. J Neurophysiol. 1997 Nov;78(5):2363-71.

Disinhibition and brain rhythms. MacVicar BA. J Physiol. 1997 Apr 15;500 ( Pt 2):283. Review.

Imaging the induction and spread of seizure activity in the isolated brain of the guinea pig: the roles of GABA and glutamate receptors. Federico P, MacVicar BA. J Neurophysiol. 1996 Nov;76(5):3471-92.

Cholinergic-dependent plateau potential in hippocampal CA1 pyramidal neurons. Fraser DD, MacVicar BA. J Neurosci. 1996 Jul 1;16(13):4113-28.

In vitro ischemia promotes calcium influx and intracellular calcium release in hippocampal astrocytes. Duffy S, MacVicar BA. J Neurosci. 1996 Jan;16(1):71-81.

Adrenergic calcium signaling in astrocyte networks within the hippocampal slice. Duffy S, MacVicar BA. J Neurosci. 1995 Aug;15(8):5535-50.

GABAA/benzodiazepine receptors in acutely isolated hippocampal astrocytes. Fraser DD, Duffy S, Angelides KJ, Perez-Velazquez JL, Kettenmann H, MacVicar BA. J Neurosci. 1995 Apr;15(4):2720-32.

Imaging cell volume changes and neuronal excitation in the hippocampal slice. Andrew RD, MacVicar BA. Neuroscience. 1994 Sep;62(2):371-83.

Potassium-dependent calcium influx in acutely isolated hippocampal astrocytes. Duffy S, MacVicar BA. Neuroscience. 1994 Jul;61(1):51-61.

Astrocytic GABA receptors. Fraser DD, Mudrick-Donnon LA, MacVicar BA. Glia. 1994 Jun;11(2):83-93. Review.

Postsynaptic potentials mediated by GABA and dopamine evoked in stellate glial cells of the pituitary pars intermedia. Mudrick-Donnon LA, Williams PJ, Pittman QJ, MacVicar BA. J Neurosci. 1993 Nov;13(11):4660-8.

Arachidonic acid inhibits sodium currents and synaptic transmission in cultured striatal neurons. Fraser DD, Hoehn K, Weiss S, MacVicar BA. Neuron. 1993 Oct;11(4):633-44.

Blockade by funnel web toxin of a calcium current in the intermediate pituitary of the rat. Williams PJ, Pittman QJ, MacVicar BA. Neurosci Lett. 1993 Jul 23;157(2):171-4.

A novel tetrodotoxin-insensitive, slow sodium current in striatal and hippocampal neurons. Hoehn K, Watson TW, MacVicar BA. Neuron. 1993 Mar;10(3):543-52.

Multiple types of calcium channels in acutely isolated rat neostriatal neurons. Hoehn K, Watson TW, MacVicar BA. J Neurosci. 1993 Mar;13(3):1244-57.

Mapping of neural activity patterns using intrinsic optical signals: from isolated brain preparations to the intact human brain. MacVicar BA, Watson TW, LeBlanc FE, Borg SG, Federico P. Adv Exp Med Biol. 1993;333:71-9.

Voltage-activated K+ currents in acutely isolated hippocampal astrocytes. Tse FW, Fraser DD, Duffy S, MacVicar BA. J Neurosci. 1992 May;12(5):1781-8.

Ca(2+)- and voltage-dependent inactivation of Ca2+ currents in rat intermediate pituitary. Williams PJ, Pittman QJ, MacVicar BA. Brain Res. 1991 Nov 8;564(1):12-8.

Imaging of synaptically evoked intrinsic optical signals in hippocampal slices. MacVicar BA, Hochman D. J Neurosci. 1991 May;11(5):1458-69.

Modulation of intracellular Ca++ in cultured astrocytes by influx through voltage-activated Ca++ channels. MacVicar BA, Hochman D, Delay MJ, Weiss S. Glia. 1991;4(5):448-55.

Quisqualate agonists occlude kainate-induced current in cultured striatal neurons. Tse FW, Weiss S, MacVicar BA. Neuroscience. 1991;43(2-3):429-36.

Electrophysiological properties of neuroendocrine cells of the intact rat pars intermedia: multiple calcium currents. Williams PJ, MacVicar BA, Pittman QJ. J Neurosci. 1990 Mar;10(3):748-56.

Synaptic modulation by dopamine of calcium currents in rat pars intermedia. Williams PJ, MacVicar BA, Pittman QJ. J Neurosci. 1990 Mar;10(3):757-63.

GABA-activated Cl- channels in astrocytes of hippocampal slices. MacVicar BA, Tse FW, Crichton SA, Kettenmann H. J Neurosci. 1989 Oct;9(10):3577-83.

A dopaminergic inhibitory postsynaptic potential mediated by an increased potassium conductance. Williams PJ, MacVicar BA, Pittman QJ. Neuroscience. 1989;31(3):673-81.

Transmitter- and voltage-activated ionic channels in astrocytes: possible role in extracellular ionic homeostasis. MacVicar BA. Acta Physiol Scand Suppl. 1989;582:49.

Kainic acid evokes a potassium efflux from astrocytes. MacVicar BA, Baker K, Crichton SA. Neuroscience. 1988 May;25(2):721-5.

Norepinephrine and cyclic adenosine 3′:5′-cyclic monophosphate enhance a nifedipine-sensitive calcium current in cultured rat astrocytes. MacVicar BA, Tse FW. Glia. 1988;1(6):359-65.

Membrane conductance oscillations in astrocytes induced by phorbol ester. MacVicar BA, Crichton SA, Burnard DM, Tse FW. Nature. 1987 Sep 17-23;329(6136):242-3.

Morphological differentiation of cultured astrocytes is blocked by cadmium or cobalt. MacVicar BA. Brain Res. 1987 Sep 8;420(1):175-7.

Dye and electrotonic coupling between cultured hippocampal neurons. O’Beirne M, Bulloch AG, MacVicar BA. Neurosci Lett. 1987 Aug 5;78(3):265-70.

Calcium activated potassium channels in cultured astrocytes. Quandt FN, MacVicar BA. Neuroscience. 1986 Sep;19(1):29-41.

Novel synaptic responses mediated by dopamine and gamma-aminobutyric acid in neuroendocrine cells of the intermediate pituitary. MacVicar BA, Pittman QJ. Neurosci Lett. 1986 Feb 14;64(1):35-40.

Depolarizing prepotentials are Na+ dependent in CA1 pyramidal neurons. Macvicar BA. Brain Res. 1985 May 6;333(2):378-81.

Uncoupling of CA3 pyramidal neurons by propionate. MacVicar BA, Jahnsen H. Brain Res. 1985 Mar 18;330(1):141-5.

Barium action potentials in regenerating axons of the lamprey spinal cord. MacVicar BA, Llinás RR. J Neurosci Res. 1985;13(1-2):323-35.

Voltage-dependent calcium channels in glial cells. MacVicar BA. Science. 1984 Dec 14;226(4680):1345-7.

Infrared video microscopy to visualize neurons in the in vitro brain slice preparation. MacVicar BA. J Neurosci Methods. 1984 Dec;12(2):133-9.

An incubation chamber for the simultaneous, on-slide treatment of brain sections with different reagents. Smithson KG, MacVicar BA, Hatton GI. Brain Res Bull. 1984 Jun;12(6):745-7.

A reliable method for immunocytochemical identification of Lucifer Yellow injected, peptide-containing mammalian central neurons. Smithson KG, Cobbett P, MacVicar BA, Hatton GI. J Neurosci Methods. 1984 Jan;10(1):59-69.

Dye-coupling between pyramidal cells of rat hippocampus in vivo. MacVicar BA, Ropert N, Krnjevic K. Brain Res. 1982 Apr 22;238(1):239-44.

Electrotonic coupling between granule cells of rat dentate gyrus: physiological and anatomical evidence. MacVicar BA, Dudek FE. J Neurophysiol. 1982 Apr;47(4):579-92.

Synaptic inputs and action potentials of magnocellular neuropeptidergic cells: intracellular recording and staining in slices of rat hypothalamus. MacVicar BA, Andrew RD, Dudek FE, Hatton GI. Brain Res Bull. 1982 Jan;8(1):87-93.

Electrotonic coupling between pyramidal cells: a direct demonstration in rat hippocampal slices. MacVicar BA, Dudek FE. Science. 1981 Aug 14;213(4509):782-5.

Paradoxical effects of lithium on field potentials of dentate granule cells in slices of rat hippocampus. MacVicar BA, Weir G, Riexinger K, Dudek FE. Neuropharmacology. 1981 May;20(5):489-96.

Dye transfer through gap junctions between neuroendocrine cells of rat hypothalamus. Andrew RD, MacVicar BA, Dudek FE, Hatton GI. Science. 1981 Mar 13;211(4487):1187-9.

Dye-coupling betwen CA3 pyramidal cells in slices of rat hippocampus. MacVicar BA, Dudek FE. Brain Res. 1980 Sep 8;196(2):494-7.

Intracellular recordings from the paraventricular nucleus in slices of rat hypothalamus. Dudek FE, Hatton GI, Macvicar BA. J Physiol. 1980 Apr;301:101-14.

Local synaptic circuits in rat hippocampus: interactions between pyramidal cells. MacVicar BA, Dudek FE. Brain Res. 1980 Feb 17;184(1):220-3.

Intracellular recordings from hippocampal CA3 pyramidal cells during repetitive activation of the mossy fibers in vitro. MacVicar BA, Dudek FE. Brain Res. 1979 May 25;168(2):377-81.